MICROSCOPY WHITE PAPERS AND CASE STUDIES

Fluorescence Microscopy Technique Provides New Views Of Biological Processes
Fluorescence Microscopy Technique Provides New Views Of Biological Processes Fluorescence microscopy has long been a powerful tool in biological research. A form known as total internal reflection fluorescence (TIRF) microscopy has more recently been used to watch biological processes unfold in real time. By taking advantage of the ability to label individual molecules with different colors of fluorescent tags, TIRF microscopy now affords scientists a view into the complex molecular assemblies that govern cellular...  Continue Reading...
Understanding Interference Tilted Excitation (LITE) Microscopy
Understanding Interference Tilted Excitation (LITE) Microscopy When the detection of a cellular or subcellular structure requires a high NA detection objective for the superior resolution and light collection efficiency, conventional fluorescence microscopy and Light Sheet Fluorescence Microscopy (LSFM) encounter challenges. Imaging these structures is difficult and could only be achieved through multi-view SPIM geometries with a 1.2 NA objective and subsequent deconvolution – an incredibly time...  Continue Reading...
Understanding Spinning Disk Confocal Microscopy
Understanding Spinning Disk Confocal Microscopy Using conventional fluorescence microscopy for biological imaging can be challenging because this technique does not construct 3-D images needed for 3-D specimens, and it is not able to gaze past cell features to view what happens inside certain biological structures. Confocal microscopy uses optical sectioning to obtain multiple, thin, 2-demensional slices of a sample to construct 3-D models. This enables studying 3-D structures with fast...  Continue Reading...
Understanding Light Sheet Microscopy
Understanding Light Sheet Microscopy Microscopy technologies are continuously striving to exploit new boundaries by aiming for smaller details, and becoming more sensitive and less noisy. Light sheet microscopy, first discovered by Richard Zsigmondy and Henry Siedentopf in 1903, is a technique that images a mostly large sample with short time intervals under healthier conditions over a longer period of time than conventional types of microscopy. This white paper introduces the...  Continue Reading...
Understanding Oblique Single Plane Illumination Microscopy (oSPIM)
Understanding Oblique Single Plane Illumination Microscopy (oSPIM) Oblique Single Plane Illumination Microscopy (oSPIM) is a platform for high resolution light sheet microscopy that combines the low photo-bleaching and photo-damage of LSFM with high magnification, high NA objectives for cellular and subcellular imaging. This paper describes how oSPIM works, its advantages over conventional fluorescence microscopy, and the equipment required for this technique.  Continue Reading...
Automation And Microscopy: Faster Test And Measurement
Automation And Microscopy: Faster Test And Measurement Nanotechnology uses the concept that constant velocity will get you to the destination faster than constantly stopped traffic. One technique puts this concept into practice via a fast nano-focus device based on a piezo-ceramic actuator embedded in a flexure guided lens positioning mechanism.  Continue Reading...
When Custom Costs Less Than Standard: The Benefits And Flexibility Of Custom Optical Assemblies
When Custom Costs Less Than Standard: The Benefits And Flexibility Of Custom Optical Assemblies Optical subsystems exist in a wide variety of configurations for a whole range of applications. Most of the parts that go into such optomechanical assemblies — laser and LED light sources, lenses, dichroics, filaments, detectors, spatial light modulators, and all the associated mechanical fixtures — are available as commercial off-the-shelf (COTS) parts. So it can be tempting to say that if you’re designing a new optical...  Continue Reading...
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MICROSCOPY PRODUCTS

5 Axis Micro Drilling Scanhead 5 Axis Micro Drilling Scanhead

The new 5 Axis Micro Drilling Scanhead is designed with high resolution, precision, and accuracy for applications requiring infinitely flexible scan beam pattern delivery. The scanhead features a wide precession angle up to 20° for variable taper and shapes.

Compact sCMOS Camera Compact sCMOS Camera

The new pco.panda 4.2 is a sCMOS sensor camera system designed to provide high quantum efficiency with low dark noise for applications including localization microscopy (PALM, STORM, dSTORM, GSDIM), light sheet fluorescence microscopy (LSFM, SPIM), structured illumination microscopy (SIM), and more. It also is housed in a compact, 65 x 65 x 65 mm3 package.

Controller for Miniature Piezo Stages – E-873 Controller for Miniature Piezo Stages – E-873

PI’s new E-873 controls miniature piezo stages of the Q-motion series for microscopy and photonics applications. Q-motion stages provide nanometer resolution at an affordable price. The E-873 is a benchtop device with options for control cabinet mounting, and has three channels with integrated power amplifiers and an interpolator. The device features a point-to-point motion and actuator mode for nanometer precision positioning at the target position.

Piezo Nanopositioning Stage Features Up To 52mm Travel Piezo Nanopositioning Stage Features Up To 52mm Travel

The N-565 is an ultra-precision linear positioner stage with NEXACT® PiezoWalk® technology, and designed with a subnanometer encoder resolution for high-end applications in bio-nanotechnology, fiber-optics, microscopy, semiconductor testing, metrology, and scientific research in beamlines and laser labs. With long 13 mm, 26 mm, or 52 mm travel ranges, high forces, and stiffness, this stepping drive does not subject to sliding friction or wear.

Near-Field Scanning Optical Microscope: MCL-NSOM Near-Field Scanning Optical Microscope: MCL-NSOM

The MCL-NSOM is a fully operational near-field scanning optical microscope manufactured on Mad City Labs’ versatile RM21™ inverted optical microscope. This instrument is designed to allow users to convert between NSOM, SPM, and fluorescence optical microscopy techniques.

Microscope For Fluorescence Microscopy Microscope For Fluorescence Microscopy

Mad City Labs’ RM21 Microscope is a microscopy platform designed to allow direct access to the entire optical pathway, and is capable of precision alignment in the X, Y, and Z axes. The Z-axis objective lens holder is aligned with the platform's optical axis and can hold a single objective lens. 

XYZ Nanopositioning System: Nano-LPMW XYZ Nanopositioning System: Nano-LPMW

The Nano-LPMW is a unique XYZ axis nanopositioning system designed to hold multiwall plates, slides, dishes, and environmental chambers. This low profile positioner has an extra-large center aperture with a 200 micron range of motion on all three axes. It is easily integrated into existing inverted optical microscopes and is compatible with numerous microscope stages.

MicroMirror TIRF System MicroMirror TIRF System

Mad City Labs' MicroMirror TIRF system is a new single molecule imaging instrument composed with high precision, high stability nanopositioning and microscopy technologies. It is designed for studying the ordered assembly and function of multi-component biomolecular machines.

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MICROSCOPY SUPPLIERS

BaySpec Inc. BaySpec Inc.

BaySpec, Inc., founded in 1999 with 100% manufacturing in the USA (San Jose, California), is a vertically integrated spectral sensing company. The company designs, manufactures and markets advanced spectral instruments, including UV-VIS-NIR-SWIR spectrometers, benchtop and portable NIR/SWIR and Raman analyzers, confocal Raman microscopes, hyperspectral imagers, mass spectrometers, and OEM spectral engines and components, for the R&D, biomedical, pharmaceuticals, chemical, food, semiconductor, health monitoring, human & animal medical devices, and the optical telecommunications industries.

Canon USA, Inc. Optoelectronic Components Canon USA, Inc. Optoelectronic Components

Canon U.S.A., Inc., is a leading provider of business-to-business, industrial and consumer digital and optical imaging solutions to the United States, Latin America and the Caribbean (excluding Mexico) markets with an increasing intent for more customized, localized products.

FLIR Systems, Inc - Research & Science FLIR Systems, Inc - Research & Science

Infrared Cameras|Infrared Imaging Subsystems|Thermal Cameras|Infrared Camera Subsystems|Ruggedized Infrared Cameras|Visual Inspection, Thermal|Infrared Surveillance|Video Inspection Systems, Thermal|Infrared Detectors|Thermal Sensors|Night Vision Cameras|Night Vision Systems|Detectors, Infrared|Detectors, Heat|Infrared Imagers|Infrared Equipment|Infrared Sensors|Security Systems, Infrared|Thermal Imaging Systems|Military Infrared Sensors|Integrated Detective Assemblies, Infrared|Optical Inspection Systems,Thermal|Thermal Camera Systems|Night Vision Components|Infrared Video Cameras|Data Acquisition Software,Infrared|Focal Plane Arrays|Machine Vision Systems, Infrared|Infrared Industrial Detectors|Infrared Inspection Systems|Automated Inspection, Infrared

Gooch & Housego PLC Gooch & Housego PLC

Gooch & Housego provides complete optical system design, engineering and manufacturing services to the aerospace & defense, industrial, life sciences and scientific research sectors, based upon the following key enabling photonic technologies: Acousto-Optics, Crystal Optics Electro-Optics, Fiber Optics and photonic packaging, Non-Linear Optics, Precision Optics including optical polishing and coatings, as well as light measurement instrumentation and services, spectral Imaging & synthesis.

Hamamatsu Corporation Hamamatsu Corporation

Photomultiplier Tubes|Arc Lamp|Photo Multiplier|Spectroscopy Systems

Iridian Spectral Technologies Iridian Spectral Technologies

Iridian Spectral Technologies is a diversified optical filter manufacturer that is an international leader in filter design and manufacture especially for application in the fields of fiber optic communications, optical spectroscopy, 3D entertainment, and in aerospace. Iridian Spectral Technologies was ranked as one of the top 150 high technology companies in Canada in the 2011 and 2012 Branham300 rankings and won the 2010 Canada Export Achievement Award for the province of Ontario sponsored by Profit magazine together with Export Development Corporation (EDC). Iridian Spectral Technologies is a global supplier with distributors in many countries particularly in Asia.

Mad City Labs, Inc. Mad City Labs, Inc.

Mad City Labs, Inc. is the leading US manufacturer of precision piezo based nanopositioning stages and nano-instrumenation.  We manufacture high performance motion control instrumentation including our innovative closed loop nanopositioning systems, high stability microscopy platforms, low cost probe microscopy and metrology solutions.  Our instruments are suitable for super resolution microscopy, metrology, imaging, photonics, interferometry and astronomy.

PCO-TECH Inc. PCO-TECH Inc.

PCO-TECH Inc., founded in 1986, is a manufacturing, sales and marketing organization offering photonic instrumentation and complete systems throughout the world

Photron, Inc. Photron, Inc.

Photron was founded in 1974 to provide manufacturing, sales and service of professional film and video equipment and photo-instrumentation

PI (Physik Instrumente) LP PI (Physik Instrumente) LP

PI (Physik Instrumente) provides the world’s broadest range of precision motion technologies for both micro- and nano-precision applications. PI is the world’s first and largest manufacturer of piezoelectric nanopositioning technology.  Started 4 decades ago as a supplier to research labs and universities, the company has grown into a business of 700+ employees and more than $100 million in global sales.

Precision Optics Corporation Precision Optics Corporation

For over 30 years, Precision Optics Corporation has provided state-of-the-art optical designs, components and complete optical systems for medical, biomedical, military (ITAR complainant) and industrial applications. As next generation techniques in these areas have advanced to use smaller and less invasive tools and equipment, Precision Optics responded with microprecision™ optical technology to provide components, assemblies, and products with sizes on the order of one millimeter and smaller.

Raptor Photonics Limited Raptor Photonics Limited

Raptor Photonics Limited, founded in 2006, is a global leader and manufacturer of high performance, industrial-grade and rugged low light digital & analogue cameras. Raptor specialises in complete cameras and core engine solutions using EMCCD, Scientific CMOS, SWIR and Vis-SWIR sensor technology.

Sensors Unlimited - UTC Aerospace Systems Sensors Unlimited - UTC Aerospace Systems

UTC Aerospace Systems (Sensors Unlimited Products), is the world’s leading manufacturer of indium gallium arsenide (InGaAs)-based imaging products. As renowned experts in shortwave infrared (SWIR) imaging, Sensors Unlimited, Inc. introduced the world to the concept of imaging in the shortwave IR spectrum with simple, compact, and uncooled cameras.

Xenics Xenics

Xenics is a well established and rapidly growing high-tech company about to enter exciting new fields of IR products and applications, serving the markets with excellent products and a strong technology background.

Zygo Corporation Zygo Corporation

Supplier of precision optics including extreme precision aspheres and freeform, meter-class flats and windows in common and exotic materials. Full electro-mechanical-optical design/prototype and manufacturing capabilities for medical, defense, military, ISR, semiconductor and industrial technology research.

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MICROSCOPY NEWS

  • Hollow Optical Antennas For Superior Photon Creation And Control
    Hollow Optical Antennas For Superior Photon Creation And Control

    Scientists at Julius-Maximilians-Universität (JMU) Würzburg in Bavaria, Germany, have introduced a novel plasmonic cavity antenna design that enhances the creation and control of photons emitted by atoms and molecules.

  • Novel Lenses Enable X-Ray Microscopy With Record Resolution
    Novel Lenses Enable X-Ray Microscopy With Record Resolution

    Scientists have developed novel lenses that enable X-ray microscopy with record resolution in the nanometre regime. Using new materials, the research team led by DESY scientist Saša Bajt from the Center for Free-Electron Laser Science (CFEL) has perfected the design of specialised X-ray optics and achieved a focus spot size with a diameter of less than ten nanometres.

  • Ultraviolet Microscope To Dramatically Speed Up Lab Tests
    Ultraviolet Microscope To Dramatically Speed Up Lab Tests

    A microscope using ultraviolet (UV) light to provide high-resolution histological images promises to significantly shorten the amount of time diagnostic tests are processed.

  • Thorlabs Releases New sCMOS Cameras
    Thorlabs Releases New sCMOS Cameras

    Thorlabs has announced the release of its new 2.1 Megapixel Quantalux sCMOS Camera based on a high-performance 1e- read-noise imager. Ideal for demanding imaging applications, the monochrome sensor can image the full frame [1920 (H) x 1080 (V)] at 50 fps with 16 Bit resolution and offers a peak quantum efficiency of 61% at 600 nm.

  • Water-Repellent Nanosheet Wrapper Enhances Biological Microscopy
    Water-Repellent Nanosheet Wrapper Enhances Biological Microscopy

    Japanese scientists have developed a unique water-repellent nanomaterial that can be wrapped around biological tissue to visualize high-quality images for a longer period of time.

  • New High Power, Low Noise, White Light Source For Microscopy
    New High Power, Low Noise, White Light Source For Microscopy

    The new Mighty Light from Spectrolight is a turnkey, compact source of broadband light based on a high power tungsten-halogen lamp which is ideal for microscopy, machine vision, photovoltaic research and testing, and other diverse illumination applications.  With a nominal color temperature of 2900K, the Mighty Light provides over 2 watts of low-noise, white light output spanning the visible through near‑infrared spectral regions (400 nm ~ 2.5 µm). 

  • Scanning Microwave Microscopy For Non-Destructive Imaging Of Silicon Nanostructures
    Scanning Microwave Microscopy For Non-Destructive Imaging Of Silicon Nanostructures

    Academe and industry collaborators in Europe have developed a scanning microwave microscope capable of imaging three-dimensional, atom-sized components buried within silicon chips, making it one of the first devices to image and characterize, in a non-destructive way, those structures that are considered building blocks of quantum devices.

  • Minimally-Invasive Brain Imaging May Be Possible With Surgical Needles
    Minimally-Invasive Brain Imaging May Be Possible With Surgical Needles

    By substituting a glass surgical needle for the endoscope, a proof-of-concept study in mice has demonstrated technology that might lead to a minimally invasive method for imaging deep brain tissue, one that could provide a better understanding of neurological conditions.

  • Non-Destructive, Sub-Angstrom Level Measurement Of A Nanofiber
    Non-Destructive, Sub-Angstrom Level Measurement Of A Nanofiber

    Researchers at the University of Maryland's Joint Quantum Institute (JQI) and the Army Research Laboratory (ARL) have devised a unique method to measure the radius of a nanofiber with sub-angstrom-scale sensitivity — without destroying the nanofiber with chemicals and heat in the process, as current scanning electron microscopy (SEM) techniques tend to do.

  • Excelitas Technologies Introduces NIR-Optimized Single Photon Counting Module
    Excelitas Technologies Introduces NIR-Optimized Single Photon Counting Module

    Excelitas Technologies® recently introduced the SPCM-NIR, a Single Photon Counting Module specifically selected and performance-optimized for the near-infrared (NIR) wavelength spectrum. This NIR-spectrum enhanced device is designed to support long-range LIDAR, quantum communication and microscopy applications, as well as many others.

  • STReM Technique Captures High-Speed, Super-Resolution Images Without Need For A Fast Camera
    STReM Technique Captures High-Speed, Super-Resolution Images Without Need For A Fast Camera

    Rice University researchers have refined a Nobel Prize-winning microscopy technique to capture fluorescing molecules at a frame rate 20 times faster than other laboratory cameras.

  • PI Launches 2nd Generation PInano® Piezo Stage For SR Microscopy
    PI Launches 2nd Generation PInano® Piezo Stage For SR Microscopy

    PI has recently released a 2nd generation of its successful PInano® product line of high resolution XY/XYZ multi-axis positioning systems. The digital servo piezo controller offers the advantage of higher linearity, simple operation, and easy access to advanced features in comparison to conventional analog piezo controllers. It provides responsive real-time tracking, and it supports PI's unique Fast Focus & Freeze capability, where the unit can be bumplessly switched from external (focus) sensor to internal (capacitive, SGS or piezoresistive) sensor, allowing precise, calibrated, stable motions with respect to the focal plane.

  • Qioptiq mag.x system 125 Now Optimized For 35 mm Camera Format Sensors
    Qioptiq mag.x system 125 Now Optimized For 35 mm Camera Format Sensors

    Qioptiq, an Excelitas Technologies® Company, recently introduces the new 1.73x Tube Lens as a widely desired addition to the mag.x system 125. Representing a new class of optical systems that enable microscope-like resolution with wide fields-of-view to support modern high-resolution sensors, the 1.73x Tube Lens makes the mag.x system 125 a perfect match for sensors with the 35 mm camera format.

  • High Power Violet Lasers Improve Cytometry And Confocal Microscopy Applications
    High Power Violet Lasers Improve Cytometry And Confocal Microscopy Applications

    A new, high power, ultra-compact, violet laser from Coherent, Inc. will provide improved performance for numerous short wavelength applications, including examples in life sciences, where it will enable brighter confocal imaging and faster flow cytometry throughput rates.

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MICROSCOPY VIDEOS

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